Subtle change to your tongue could be early warning sign for devastating MND
Motor Neurone Disease (MND) can affect adults of any age, but it is more prevalent in those over 50
Magnetic resonance imaging (MRI) scans are vital instruments for diagnosing medical conditions and examining the well-being of bones and organs. Now, scientists believe they could also detect early warning signs of Motor Neurone Disease (MND) by examining our tongues more closely.
MND is a progressive condition that reduces life expectancy by targeting the nerves that control movement, called motor neurons. This typically results in muscle deterioration, making speech, breathing, movement, and swallowing challenging, with symptoms deteriorating over months or years.
The fresh research, carried out by the University of Queensland in Australia, found that people with MND who experience difficulties with speaking or swallowing typically possess reduced tongue muscle mass. Researchers now believe this could function as an early warning sign of the brain-degenerative illness.
Neuroscientist Dr Thomas Shaw, who led the study, said: "There are eight interconnected muscles in our tongues, each with a different role allowing us to eat, swallow and speak. But for someone with a motor neuron disease, the tongue muscles – like many others in the body – progressively weaken and sadly, waste away.
"Being able to detect and track this symptom early would help patients and clinicians, especially with interventions like early access to clinical trials."
MRI scans typically last between 15 minutes and an hour, although they can occasionally take longer. Dr Shaw noted that examining tongue muscles within someone's mouth can be highly invasive, but a routine MRI brain scan frequently captures images of them. Due to this, the team reviewed more than 200 historical MRI scans for the study, including numerous from individuals living with MND.
AI-supported technologies and cutting-edge imaging methods were then employed to obtain accurate measurements of tongue muscle volume and form. Cross-sectional comparisons revealed notable differences between the scans of people with MND and those without.
Among them, people with MND symptoms affecting the mouth, tongue, throat, and neck muscles were found to have a shorter survival time compared to those whose symptoms started in their limbs.
Dr Shaw continued: "This played out in our own results – people with lower tongue volumes had a worse prognosis. So importantly, this measurement can potentially tell us about both life expectancy for people living with MND and faster diagnosis, which in turn can assist in planning and speedier enrolment into clinical trials."
The study's data and approaches are now publicly available, seeking to support and enhance further research. Dr Shaw added: "There’s currently a lag of around 12 months between someone experiencing MND symptoms and their diagnosis, so getting earlier access to treatment and support, enrolment in clinical trials and voice banking is the goal.
"This method could also be used to study countless existing MRI datasets, helping unlock insights into a range of other health conditions including speech disorders and cancer."
Symptoms of MND
Motor Neurone Disease (MND) can affect adults of any age, but it is more prevalent in those over 50. Unfortunately, there is currently no cure for MND, but treatments are available to help manage its symptoms.
According to the NHS, its initial symptoms may include:
- Weak legs and feet - you may have difficulty climbing stairs, you may trip over a lot, and you may find it difficult to lift your feet
- Twitches, spasms or muscle cramps
- Stiff or weak hands
As MND progresses, you may also experience:
- An inability to walk
- Difficulty breathing, swallowing or speaking
- Producing a lot of saliva
- Have changes in your mood or personality
Amyotrophic lateral sclerosis (ALS) is the most common form of MND, but there are four main types, each affecting people differently.
When should you see a doctor?
It's crucial to understand that early symptoms of MND can mimic other, less serious conditions. Therefore, experiencing muscle weakness or spasms doesn't necessarily indicate MND.
However, the NHS particularly urges those experiencing three key symptoms to seek GP advice:
- Difficulty holding or gripping objects
- Weakness in your legs or feet
- Twitches or muscle cramps that keep happening, last a long time or do not go away
Its official advice adds: "If a GP thinks you might have motor neurone disease (MND), they may refer you to a brain and nerve specialist (neurologist) for an assessment and some tests.
"...MND can be difficult to diagnose in the early stages. But as the symptoms get worse it can usually be confirmed."